Week 1 NFL Odds
See how each game stacks up for point spreads, game totals, and stackability for NFL DFS contests.
Source: DraftKings Sportsbook, via ESPN
Updated: Sept 3, 2026
Note: Lines move before kickoff — treat as a snapshot, not final.
Wednesday
September 9Patriots @ Seahawks
8:20 PM ET · NBC
SEA -3.5
Spread
SEA -175 / NE +145
Moneyline
44.5
Total
Thursday
September 10 · Melbourne, Australia49ers @ Rams
8:35 PM ET · Netflix
LAR -3.5
Spread
LAR -198 / SF +164
Moneyline
48.5
Total
Sunday
September 13Saints @ Lions
Sunday, Sept 13
DET -7
Spread
DET -298 / NO +240
Moneyline
49.5
Total
Bears @ Panthers
1:00 PM ET · FOX
CHI -2.5
Spread
CHI -155 / CAR +130
Moneyline
47.5
Total
Ravens @ Colts
1:00 PM ET
BAL -3.5
Spread
BAL -175 / IND +145
Moneyline
48.5
Total
Falcons @ Steelers
Sunday, Sept 13
PIT -3.5
Spread
PIT -185 / ATL +154
Moneyline
42.5
Total
Browns @ Jaguars
Sunday, Sept 13
JAX -7.5
Spread
JAX -395 / CLE +310
Moneyline
40.5
Total
Buccaneers @ Bengals
1:00 PM ET · FOX
CIN -3.5
Spread
CIN -198 / TB +164
Moneyline
50.5
Total
Bills @ Texans
Sunday, Sept 13
BUF -1.5
Spread
BUF -118 / HOU -102
Moneyline
44.5
Total
Jets @ Titans
Sunday, Sept 13
TEN -1.5
Spread
TEN -130 / NYJ +110
Moneyline
38.5
Total
Commanders @ Eagles
4:25 PM ET · FOX
PHI -5.5
Spread
PHI -218 / WAS +180
Moneyline
45.5
Total
Cardinals @ Chargers
Sunday, Sept 13
LAC -10.5
Spread
LAC -550 / ARI +410
Moneyline
46.5
Total
Dolphins @ Raiders
4:25 PM ET · FOX
LV -3.5
Spread
LV -198 / MIA +164
Moneyline
40.5
Total
Packers @ Vikings
4:25 PM ET · CBS
MIN -1.5
Spread
MIN -118 / GB -102
Moneyline
45.5
Total
Cowboys @ Giants
8:20 PM ET · NBC
DAL -2.5
Spread
DAL -148 / NYG +124
Moneyline
48.5
Total
Monday
September 14Broncos @ Chiefs
8:15 PM ET · ESPN/ABC
KC -3
Spread
KC -148 / DEN +124
Moneyline
42.5
Total
Best Stacking Spots for Sunday’s Main Slate
Games with the highest totals and the tightest spreads — the profile that points to a competitive script both offenses stay involved in, which is where DFS stacks tend to pay off.
NO. 1 · HIGHEST TOTAL OF THE SLATE
Buccaneers @ Bengals
Total 50.5
Spread CIN -3.5
The highest total on Sunday paired with a manageable field-goal-range spread. Plenty of room for both passing games to get there — good spot for a Bengals stack with Tampa Bay pass-catchers as a pivot.
NO. 2 · SECOND-HIGHEST TOTAL
Saints @ Lions
Total 49.5
Spread DET -7
The spread is wider than the others on this list, but the total says this stays an up-tempo, scoring-heavy game. Detroit’s offense is the clear centerpiece stack, with New Orleans catch-up volume as the bring-back.
NO. 3 · TIGHT SPREAD, SOLID TOTAL
Bears @ Panthers
Total 47.5
Spread CHI -2.5
One of the tighter spreads on the board with a total that supports both offenses staying on the field. Early-window game script risk is low here relative to the week’s bigger blowout lines.
NO. 4 · HIGH-IMPLIED FAVORITE
Cardinals @ Chargers
Total 46.5
Spread LAC -10.5
The widest spread on this list, but the total pencils the Chargers in near 28 implied points. Less about a competitive script and more about rostering the favorite’s offense outright — lean Chargers stack, fade the bring-back.
Playing DFS since the days of DraftStreet, Kevin knows the ins and outs of DFS, specifically for NFL and NBA. He’s also been helping people win in fantasy football leagues for 15+ years and is one of many experts featured at FantasyPros.
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